Dr. Donald Vinh is one of the authors of the 2 studies in Science

Two studies published in Science by an international consortium of researchers, in which Dr. Donald Vinh is involved, provide a first answer to a crucial question: why does the individual vulnerability to COVID-19 vary so much in the population?

The findings show that about 15 percent of patients who suffer from life-threatening COVID-19 have one thing in common: a defect in the activity of type I interferons (IFNs), molecules of the immune system that normally have a powerful antiviral activity. This defect is either caused by the presence of auto-antibodies directed against those molecules or by genetic abnormalities that decrease their production. These findings could make it possible to detect people at risk of developing a severe form of the disease in all age groups and to better treat patients with these conditions. — MUHC Website

Congratulations to Dr. Vinh, and also Dr. Matthew Cheng (listed as COVID Clinicians), for this high impact work!

Read More:

  1. MUHC Website
  2. Auto-antibodies against type I IFNs in patients with life-threatening COVID-19 (original article)
  3. Inborn errors of type I IFN immunity in patients with life-threatening COVID-19 (original article)
  4. Radio-Canada (French)

IDIGH Calendar

<<  <  October 2020  >  >>
 Mo  Tu  We  Th  Fr  Sa  Su 
     1  2  3  4
  5  6  7  8  91011
121315161718
192022232425
2627293031 

Latest IDIGH Publications

  1. Colaco, K., Widdifield, J., Luo, J., Rosen, C. F., Alhusayen, R., Paterson, J. M., Campbell, W., Tu, K., Bernatsky, S., Gladman, D. D. & Eder, L.
    (2020)
    .
    Trends in Mortality and Cause-specific Mortality among patients with Psoriasis and Psoriatic Arthritis in Ontario, Canada
    .
    Journal of the American Academy of Dermatology
  2. Planas, D., Fert, A., Zhang, Y., Goulet, J.-P., Richard, J., Finzi, A., Ruiz, M. J., Marchand, L. R., Chatterjee, D., Chen, H., Salinas, T. R. W., Gosselin, A., Cohen, E. A., Routy, J.-P., Chomont, N. & Ancuta, P.
    (2020)
    .
    Pharmacological Inhibition of PPARy Boosts HIV Reactivation and Th17 Effector Functions, While Preventing Progeny Virion Release and de novo Infection
    .
    Pathogens & immunity
    ,
    vol
    .
    5
    ,
    p
    .
    177-239
    .
  3. Ghanem, M., Dubé, J.-Y., Wang, J., McIntosh, F., Houle, D., Domenech, P., Reed, M. B., Raman, S., Buter, J., Minnaard, A. J., Moody, D. B. & Behr, M. A.
    (2020)
    .
    Heterologous Production of 1-Tuberculosinyladenosine in Mycobacterium kansasii Models Pathoevolution towards the Transcellular Lifestyle of Mycobacterium tuberculosis
    .
    mBio
    ,
    vol
    .
    11
  4. Cheng, M. P., Lee, T. C., Tan, D. H. S. & Murthy, S.
    (2020)
    .
    .
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
    ,
    vol
    .
    192
    ,
    p
    .
    E1296-E1298
    .
  5. Kpokiri, E. E., Marley, G., Tang, W., Fongwen, N., Wu, D., Berendes, S., Ambil, B., Loveday, S.-J., Sampath, R., Walker, J. S., Matovu, J. K. B., Boehme, C., Pai, N. P. & Tucker, J. D.
    (2020)
    .
    Diagnostic Infectious Diseases Testing Outside Clinics: A Global Systematic Review and Meta-analysis
    .
    Open forum infectious diseases
    ,
    vol
    .
    7
    ,
    p
    .
    ofaa360
    .
More publications